International Conference on Advanced Nanomaterials and Nanotechnology
Sunday, June 29, 2025
Thursday, June 26, 2025
Nanomedicine
Nanomedicine
branch of medicine that seeks to apply nanotechnology—that is, the manipulation and manufacture of materials and devices that are roughly 1 to 100 nanometres (nm; 1 nm = 0.0000001 cm) in size—to the prevention of disease and to imaging, diagnosis, monitoring, treatment, repair, and regeneration of biological systems.
Since the emergence of nanomedicine in the 1990s, a number of applications have been developed. Research has focused in particular on the development of biosensors to aid in diagnostics and vehicles to administer vaccines, medications, and genetic therapy, including the development of nanocapsules to aid in cancer treatment. A major breakthrough in nanomedicine occurred in 2020, when the application of nanotechnology helped accelerate the development of mRNA-based COVID-19 vaccines.
An offshoot of nanotechnology, nanomedicine is an emerging field and had garnered interest as a site for global research and development, which gives the field academic and commercial legitimacy. Funding for nanomedicine research comes both from public and private sources, and the leading investors are the United States, the United Kingdom, Germany, and Japan. In terms of the volume of nanomedicine research, these countries are joined by China, France, India, Brazil, Russia, and India.
Working at the molecular-size scale, nanomedicine is animated with promises of the seamless integration of biology and technology, the eradication of disease through personalized medicine, targeted drug delivery, regenerative medicine, as well as nanomachinery that can substitute portions of cells. Although many of these visions may not come to fruition, some nanomedicine applications have become reality, with the potential to radically transform the practice of medicine, as well as current understandings of the health, disease, and biology—issues that are of vital importance for contemporary societies. The field’s global market share totalled some $78 billion dollars in 2012, driven by technological advancements. By the end of the decade, the market is expected to grow to nearly $200 billion.
Development
Nanomedicine derives much of its rhetorical, technological, and scientific strength from the scale on which it operates (1 to 100 nm), the size of molecules and biochemical functions. The term nanomedicine emerged in 1999, the year when American scientist Robert A. Freitas Jr. published Nanomedicine: Basic Capabilities, the first of two volumes he dedicated to the subject.
Extending American scientist K. Eric Drexler’s vision of molecular assemblers with respect to nanotechnology, nanomedicine was depicted as facilitating the creation of nanobot devices (nanoscale-sized automatons) that would navigate the human body searching for and clearing disease. Although much of this compelling imagery still remains unrealized, it underscores the underlying vision of doctors being able to search and destroy diseased cells, or of nanomachines that substitute biological parts, which still drives portrayals of the field. Such illustrations remain integral to the field, being used by scientists, funding agencies, and the media alike.
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Research and development projects on nanomaterials
OECD Test Guideline development for nanomaterials: Transformation of nanomaterials under environmental conditions
In addition to their agglomeration (dispersion stability) and dissolution, whether and how nanomaterials are transformed over time via abiotic processes is also important for their behaviour and fate in the environment. This knowledge is significant to understand in which form and amount engineered nanomaterials are present in the environment. The research project aims to develop an OECD test guideline for a quantitative determination of the abiotic transformation processes of nanomaterials, taking into account relevant environmental parameters. The work builds on ongoing activities for the development of an OECD Guidance Document on environmental abiotic transformation of nanomaterials.
In addition, the project will also include investigations to validate a possible test protocol for determining the heteroagglomeration of nanomaterials under consideration of relevant environmental parameters. The basis for this will be the existing OECD test guideline 318 for the determination of dispersion stability of nanomaterials under environmental conditions, which is currently limited to the investigation of homoagglomeration of nanomaterials. (UFORDAT No. 01088269)
Examination and further development of strategic approaches for dealing with advanced materials in chemical safety“ – Study on nanocarriers and their environmental behaviour
The project considers nanocarriers as a case study for advanced materials that pose challenges for risk assessment under EU chemicals legislation. In the project, literature research on existing nanocarriers or those under development and their (potential) applications will be carried out. From the overview thus obtained, three nanocarrier types and the active substances they contain will be selected as examples for further investigations. These nanocarriers are expected to pose particular challenges for risk assessment in terms of material properties, environmental behavior and specific applications (e.g. in medicine or agriculture). For the selected nanocarriers, test strategies will be (further) developed and implemented in the laboratory in order to investigate their environmental behaviour and the potential release of the transported active ingredient under environmentally relevant conditions in more detail. The focus here is on assessing the mobility and degradability of the nanocarrier in aquatic systems as well as the non-intentional release of the active ingredient. The objectives of this research project are: (1) to discuss the preliminary project results in technical meetings with selected stakeholders in order to (2) identify knowledge gaps with regard to the environmental risk assessment of nanocarriers and (3) to develop proposals for the adaptation of existing concepts for assessment. In this way, the project should contribute to the development of a comprehensive risk assessment of the environmental behaviour of nanocarriers. (UFORDAT No. 01103855)
Investigation of ecotoxicological effects of fibrous and platelet-shaped advanced materials for deriving adapted testing strategies
Fibrous and platelet-shaped advanced materials, such as carbon nanotubes, graphenes or MXenes, exhibit exceptional mechanical, electronic, optical and chemical properties. They are therefore being investigated for a variety of applications. These include, for example, optoelectronic applications (e.g. solar cells, light-emitting diodes), sensor technology, composite materials (e.g. for electrical conductivity, EMC shielding), energy storage, catalysts or textiles (e.g. for electrical conductivity, flame retardancy). Fibrous and platelet-like advanced materials may pose methodological challenges for regulatory risk assessment under EU chemical legislation due to their properties. The mechanisms contributing to the ecotoxic effects of these materials are poorly understood. In addition, there is concern that potential ecotoxic effects of the materials are not adequately elucidated via classical methods. Thus, there is a need to develop appropriate testing strategies to identify relevant mechanisms and (sub)lethal effects that allow a specific assessment of the ecotoxic potential of fibrous and platelet advanced materials. In this project, specific mechanisms of action and relevant (sub)lethal effects of these materials will be investigated based on a literature review. Based on that it will be derived which test systems must be used in order to be able to make specific statements on the ecotoxicology of these materials. Selected test systems will be tested and adapted using selected fibrous and platelet materials as examples. In this way, recommendations will be derived as to how non-classical effects could be taken into account in the environmental risk assessment of such materials and what further steps would have to be taken.
International Research Awards on Advanced Nanomaterials and NanotechnologyWednesday, June 25, 2025
Tuesday, June 24, 2025
Monday, June 23, 2025
Dr. Jianliang Lin
International Research Awards on Advanced Nanomaterials and Nanotechnology
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